阿尔兹海默症基因表达 PCR 芯片包含了 84 个可用于研究老年痴呆症发生与发展的重要基因。该芯片包括与β- 淀粉样蛋白（Aβ）的产生、清除和降解有关的基因，还包括β-淀粉样蛋白（Aβ）信号转导途径中参与神经毒性和炎症反应的基因。利用该芯片研究者即能够利用该芯片简单可靠地同时检测阿尔兹海默症相关基因的表达。

Beta-Amyloid Geneion, Oligomerization, Clearance, & Degradation:

Secretases: ADAM9, APH1A, BACE1, BACE2, CTSB, NCSTN, PSEN1, PSEN2.

Other Peptidases: IDE, PLAT (tPA), PLAU (uPA), PLG.

Endocytosis: APLP1, APP, LRP1, LRP6, LRP8.

Other Genes: A2M, ACHE, APBB1, APBB2, APOE, BCHE, UBQLN1.

Cytoskeleton Reorganization: APOE, MAP2, MAPT, PKP4, PRKCI.

Synaptic Formation: ACHE, APBA1, APBB1, APBB2, APOE, BDNF, CHAT.

Lipid Metabolism: ABCA1, APOA1, APOE, CLU, HSD17B10 (HADH2), INS, LPL, LRP1, LRP8, SNCB.

Apoptosis: APLP1, APP, CASP3, CASP4, CLU, EP300, ERN1, IL1A, MAPT, MPO, NAE1, PRKCA, PRKCE, PRKCZ, PSEN1, PSEN2, SNCA.

Cell Cycle: APBB1, APBB2, CDK1 (CDC2), CDK5, CDKL1, ERN1, EP300, IL1A, NAE1, PRKCA.

Cell Signaling Molecules: WNT Signaling: GSK3A, GSK3B, LRP6.

Notch Signaling: ADAM10, APH1A, NCSTN, PSEN1, PSEN2.

G-protein Coupled Receptor Signaling: APLP2, GNAO1, GNAZ, GNB1, GNB4, GNB5, GNG11, GNG3, GNG4, GNGT1, GNGT2, NTRK1, NTRK2.

Intracellular Signaling: APBA3, APBB2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PRKCI, PRKCQ, PRKCZ, PSEN1, PSEN2.

Other Genes: GAP43, GNB2, IDE, IL1A, INSR, NAE1, PLAU (uPA).

Transcription: APBB1, APBB2, EP300, ERN1.

Oxidative Stress: HSD17B10 (HADH2), MPO, UQCRC1, UQCRC2.

Proteases & Inhibitors: ADAM10, APLP2, APP, CAPN1, CTSC, CTSD, CTSG, CTSL1, SERPINA3, UQCRC2.